The front and rear of collective cell migration

Mayor, Roberto, and Sandrine Etienne-Manneville. “The front and rear of collective cell migration.” Nature Reviews Molecular Cell Biology (2016). Summary & Highlights Collectively migrating group of cells is that it migrates more efficiently than if cells were isolated Cells become leaders in response to external cues, which include the ECM, soluble factors and neighbouring cells… Read More The front and rear of collective cell migration

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell–cell contacts upon externally applied stretch

Borghi, Nicolas, et al. “E-cadherin is under constitutive actomyosin-generated tension that is increased at cell–cell contacts upon externally applied stretch.” Proceedings of the National Academy of Sciences 109.31 (2012): 12568-12573. Summary & Highlights Cadherins: intercellular adhesion complexes Extracellular: form bonds with cadherins on neighboring cells Intracellular: recruits catenin, associate with additional cytoskeleton binding and regulatory proteins// binds beta-catenin,… Read More E-cadherin is under constitutive actomyosin-generated tension that is increased at cell–cell contacts upon externally applied stretch

Collective cell durotaxis emerges from long-range intercellular force transmission

Raimon Sunyer, Vito Conte, Jorge Escribano, Alberto Elosegui-Artola, Anna Labernadie, Léo Valon, Daniel Navajas, José Manuel García-Aznar, José J. Muñoz, Pere Roca-Cusachs and Xavier Trepat (September 8, 2016) Science 353 (6304), 1157-1161. [doi: 10.1126/science.aaf7119]   Summary & Highlights Ability of cell to follow ECM stiffness = durotaxis “Here, we found multicellular clusters that exhibited durotaxis… Read More Collective cell durotaxis emerges from long-range intercellular force transmission

A collective route to metastasis: Seeding by tumor cell clusters

Kevin J. Cheung and Andrew J. Ewald (April 7, 2016) Science 352 (6282), 167-169. [doi: 10.1126/science.aaf6546] Summary & Highlights “Although conventional models suggest that metastases are seeded by single cells from the primary tumor, there is growing evidence that seeding requires the collective action of tumor cells traveling together in clusters.” Carcinomas typically arise from… Read More A collective route to metastasis: Seeding by tumor cell clusters